The framework

A comparable number for the value of evidence.

Return on Evidence (ROE) scores evidence activities, assets, and portfolios on one scale, so leaders can fund what creates value, redirect what does not, and defend evidence decisions with a clear rationale.


The problem

Everyone agrees evidence matters. No one agrees what a given study is worth.

Evidence generation is often funded by argument, seniority, precedent, and urgency, not by a shared measure of value. That makes spend hard to defend internally and harder to optimize across a portfolio.

Where ROE fits

ROE works because the evidence record is connected first.

ROE is not a spreadsheet exercise. It is computed inside EvidenceSync from the same governed evidence record your teams already work in. Plans, claims, gaps, actions, activities, data sources, stakeholders, and dissemination outputs are connected before value is scored. In the canonical workflow, ROE is stage 06, Prioritize, and it only carries weight because stages 01 to 05 happened first.

The formula

Four factors, one comparable score.

ROE = ( IEV × AIF × VIF ) / TRC
IEV· Intrinsic evidence value: the expected scientific, clinical, regulatory, or commercial value of the evidence output itself.
AIF· Asset impact factor: the degree to which the evidence affects asset-level decisions, differentiation, lifecycle strategy, or label and market positioning.
VIF· Value influence factor: the degree to which the evidence can influence external stakeholder decisions, including regulators, payers, HCPs, guideline bodies, or internal governance.
TRC· Total realized cost: the full cost to generate, validate, disseminate, govern, and defend the evidence.

ROE weighs the value an evidence activity creates against what it truly costs to realize. Because every input is defined the same way, any two things can be compared on the same scale.

Three tiers

From the boardroom to the single study.

T1 · Portfolio ROEBoard-level view of where evidence dollars create the most defensible value across the book.
T2 · Asset ROEPer-asset return, with competitive positioning treated as a first-class input, not an afterthought.
T3 · Activity ROEThe unit decision: fund this study, this analysis, this publication, this dissemination activity, or redirect the spend.
Gap and action prioritization

ROE turns gap intelligence into funding discipline.

Once EvidenceSync identifies a gap and defines a recommended action, ROE helps teams decide whether that action deserves funding, review, deferral, escalation, or retirement. The score makes prioritization explicit instead of political.

Gap detected · 04Action defined · 05ROE scored · 06Review routed · 07Decision recorded
Methodology

The full weighting methodology is available on request.

A plain-language walkthrough of how inputs are scored is available to evaluation teams. The full weighting methodology, including coefficients, is shared under the walkthrough rather than published here.

Request the methodology briefing

See ROE applied
to your portfolio.

A focused walkthrough with the team, tailored to your prioritization questions.